
Aguayo Hernández Luis Gerardo
Doctor en Farmacología
Facultad de Ciencias Biológicas
laguayo@udec.cl
PROYECTOSPUBLICACIONESLIBROS Y REVISTAS
Aguayo Hernández Luis Gerardo
Proyectos
- Mechanisms for potentiation of glycine receptors by ethanol. NIH R01AA025718. 2017-2022. Director General.
- Novel anti neurodegenerative molecules that block multiple steps in the amyloid cascade. FONDECYT. 2018-2022. Investigador principal.
- Rational design of bioisosteric derivatives of lead compounds that inhibit the ethanol effects on glycine receptor. FONDECYT. 2017-2020. Coinvestigador.
- Identificación de moléculas pequeñas con actividad inhibitoria sobre efectos de etanol en el receptor de glicina in vitro e in vivo a través de unión a la proteína gby. VRID. 2016-2108. Coinvestigador.
- Creación de una plataforma de innovación en Biotecnología aplicada al sector biomédico y veterinario. Gestor y Miembro del Comité Ejecutivo. PROYECTO PMI UCO 20154. 2015-2018. Investigador Principal.
- Characterization of glycine receptor molecular determinants and alcohol depressant action. Conicyt-UK Collaborative Project Overlap: This is a small exploratory grant of $20,000 for operation costs, alpha 2 animal purchase and transport, personnel training and outreach. There is minimal overlap since main experiments deal with gephyrin, screening for novel compounds and studies in PFC and VTA. 2014-2017. Investigador principal.
- Molecular determinants for the neurotoxic action of beta amyloid peptides. FONDECYT. 2014-2017. Investigador principal.
- Optimizar equipamiento del bioterio para fortalecer la investigación biomédica en la universidad de concepción. FONDEQUIP. 2014-2016. Investigador principal.
- Development and characterization of molecules having clinical use in acute ethanol intoxication. PROJECT IDEA. 2013-2015. Investigador principal.
- Cellular and Molecular Determinants of Puringergic Contribution to Neuronal Dyshomeostasis in Alzheimer´s Disease. FONDECYT. 2013-2016. Coinvestigador.
- Glycine receptor alpha 1 ex`pression, splicing and subcellular distribution in the central nervous system of c57bl/6 and kk385-386aa knock-in mice. FONDECYT. 2013-2016. Investigador alterno.
Aguayo Hernández Luis Gerardo
Publicaciones
- Saez-Orellana F, Fuentes-Fuentes MC, Godoy PA, Silva-Grecchi T, Panes JD, Guzman L, Yevenes G, Gavilan J, Egan TM, Aguayo LG, Fuentealba J. P2X receptor overexpression induced by soluble oligomers of amyloid beta peptide potentiates synaptic failure and neuronal dyshomeostasis in cellular models of Alzheimer´s disease. 2018. Neuropharmacology 128:366-378.
- Vidal F, Vasquez P, Cayuman FR, Diaz C, Fuentealba J, Aguayo LG, Yevenes GE, Alderete J, Guzman L. Prevention of synaptic alterations and neurotoxic effects of PAMAM dendrimers by surface functionalization. 2018. Nanomaterials (Basel) 25:8(1).
- Aguayo S, Schuh CMAP, Vicente B, Aguayo LG. Association between Alzheimer´s disease and oral and gut microbiota: Are pore forming proteins the missing link? 2018. J Alzheimers Dis. 2018;65(1):29-46.
- Muñoz B, Yevenes GE, Forstera B, Lovinger DM, Aguayo LG. Presence of inhibitory glycinergic transmission in medium spiny neurons in the nucleus accumbens. Front Mol Neurosci. 2018 Jul 11;11:228.
- Fernandez-Perez EJ, Sepulveda FJ, Peters C, Bascuñan D, Riffo-Lepe NO, Gonzalez-Sanmiguel J, Sanchez SA, Peoples RW, Vicente B, Aguayo LG. Effect of cholesterol on membrane fluidity and association of amyloid beta oligomers and subsequent neuronal damage: A double-edged sword. 2018. Front Aging Neurosci. Aug 3;10:226.
- Forstera, B., Muñoz, B., Lobo, MK., Chandra, R., Lovinger, DM., Aguayo, LG. Presence of ethanol sensitive glycine receptors in medium spiny neurons in the mouse nucleus accumbens. 2017. The Journal of Physiology. 595(15):5285-5300.
- Fernandez-Perez, EJ., Sepulveda, FJ., Peoples, R., Aguayo, LG. Role of membrane GM1 on early neuronal membrane actions of Aβ during onset of Alzheimer´s disease. 2017. Biochim Biophys Acta 1863(12): 3105-3116.
- Saez-Orellana, F., Godoy, PA., Bastidas, CY., Silva-Grecchi, T., Guzman, L., Aguayo, LG., Fuentealba. ATP leakage induces P2XR activation and contributes to acute synaptic excitotoxicity induced by soluble oligomers of beta amyloid peptide in hippocampal neurons. 2016. J. Neuropharmacology 100:116-23.
- Peters, C., Bascuñan, D., Opazo, C., Aguayo, LG. Differential membrane toxicity of amyloid-β fragments by pore forming mechanisms. 2016. J. Alzheimers Dis. 51(3):689-99.
- Peters, C., Sepulveda, FJ., Fernandez-Perez, EJ., Peoples, RW., Aguayo, LG. The level of NMDA receptor in the membrane modulates amyloid-β association and perforation. J. Alzheimers Dis. 53:197-207. (2016)
- Forstera, B., Castro, PA., Moraga-Cid, G., and Aguayo, LG. Potentiation of gamma aminobutyric acid receptors (GABAAR) by ethanol: How are inhibitory receptors affected? 2016. Frontiers in Cellular Neuroscience Volume 10: Article 114.
- Burgos, CF., Yevenes, GE., Aguayo, LG. Structure and pharmacological modulation of inhibitory glycine receptors. 2016. Molecular Pharmacology, 90(3):318-25.
- San Martin, L., Cerda, F., Jin, C., Jimenez, V., Yevenes, GE., Hernandez, T., Nova, D., Fuentealba, J., Aguayo, LG., Guzman, L. Reversal of ethanol-induced intoxication by a novel modulator of Gβγ potentiation of glycine receptor. 2016. Journal of Biological Chemistry 291(36):18791-8.
- Lara, CO., Murath, P., Muñoz, B., Marileo, AM., San Martin, L., San Martin, VP., Burgos, CF., Mariqueo, TA., Aguayo, LG., …, Yevenes, GE. Functional modulation of glycine receptors by the alkaloid gelsemine. 2016. British Journal of Pharmacology. 173(14):2263-77.
- Fernandez-Perez, EJ., Peters, C., Aguayo, LG. Membrane damage induced by amyloid beta and a potential link with neuroinflammation. 2016. Current Pharmaceutical Design. 22(10):1295-304.
- Sanchez A, Yevenes GE, San Martin L, Burgos CF, Moraga-Cid G, Harvey RJ, Aguayo LG. Control of ethanol sensitivity of the glycine receptor alpha 3 subunit by transmembrane 2, the intracellular splice cassette and C-terminus domain. 2015. Journal of Pharmacology and Experimental Therapeutics. 353:80-90.
- Peters, C., Espinoza, MP., Gallegos, S., Opazo, C., Aguayo, LG. Alzheimer´s Aβ interacts with cellular prion protein inducing neuronal membrane damage and synaptotoxicity. 2015. Neurobiology of Aging 36(3):1369-77.
- Burgos, CF., Muñoz, B., Guzman, JL., Aguayo , LG. Ethanol effects on glycinergic transmission: From molecular pharmacology to behavior responses. 2015. Pharmacological Research. 101:18-29.
- Burgos, CF., Castro, PA., Mariqueo, T., Bunster, M., Guzman, L., Aguayo, LG. Evidence for alpha-helices in the large intracellular domain mediating modulation of the alpha 1 glycine receptor by ethanol and Gβγ. 2015. J. Pharmacology and Exp. Ther. 352(1):148-55.
- Ramirez, AE., Muñoz, FJ., Gallegos, SS., Caviedes, PA., Aguayo, LG., Opazo, CM. Extracellular alpha-synuclein alters synaptic transmission in brain neurons by perforating the neuronal plasma membrane. 2015. Journal of Neurochemistry. 132(6):731-741.
- Gallegos, S., Pacheco, C., Peters, C., Opazo, CM., Aguayo, LG. Features of alpha-synuclein that could explain the progression and irreversibility of Parkinson´s disease. 2015. Front. Neurosci. 9:59 (pg1-11).
- Muñoz, G., Urrutia, JC., Burgos, CF., Silva, V., Aguilar, F., Sama, M., Yeh, HH., Opazo, C., Aguayo, LG. Low concentrations of ethanol protect against synaptotoxicity induced by Aβ in hippocampal neurons. 2015. Neurobiology of Aging 36(2):845-56.
- Castro, PA., Ramirez, A., Sepulveda, FJ., Peters, C., Fierro, H., Waldron, J., Luza, S., Fuentealba, J., Muñoz, FJ., De Ferrari, GV., Bush, AI., Aguayo, LG., Opazo, CM. Copper-uptake is critical for the down regulation of synapsin and dynamin induced by neocuproine: modulation of synaptic activity in hippocampal neurons. 2014. Front Aging Neurosci. 6: 319 (pgs1-10).
- Sepulveda, FJ., Fierro, H., Fernandez, E., Castillo, C., Peoples, RW., Opazo, C., Aguayo, LG. Nature of the neurotoxic membrane actions of amyloid-β on hippocampal neurons in Alzheimer´s disease. 2014. Neurobiology of Aging 35(3):472-81.
- Mariqueo, TA., Agurto, A., Muñoz, B., San Martin, L., Coronado, C., Fernandez-Perez, EJ., Murath, P., Sanchez, A., Homanics, GE., Aguayo, LG. Effects of ethanol on glycinergic synaptic currents in mouse spinal cord neurons. 2014. J. Neurophysiology 111(10):1940-8.
- Aguayo, LG., Castro, P., Mariqueo, T., Muñoz, B., Xiong, W., Zhang, L., Lovinger, DM., Homanics, GE. Altered sedative effects of ethanol in mice with α1 glycine receptor subunits that are insensitive to Gβγ modulation. 2014. Neuropsychopharmacology 39(11):2538-48.
- Ramirez, AE., Pacheco, CR., Aguayo, LG., Opazo, CM. Rapamycin protects against Aβ-induced synaptotoxicity by increasing presynaptic activity in hippocampal neurons. 2014. Biochem Biophys Acta 1842(9):1495-1501.
- Araya, J. A., Ramirez, A. E., Figueroa-Aroca, D., Sotes, G. J., Perez, C., Becerra, J., Saez-Orellana, F., Guzman, L., Aguayo, L. G., and Fuentealba, J. Modulation of neuronal nicotinic receptor by quinolizidine alkaloids causes neuroprotection on a cellular Alzheimer model. 2014. Journal of Alzheimer’s disease : JAD 42, 143-155.
- Bustos, FJ., Varela-Nallar, L., Campos, M., Henriquez, B., Phillips, M., Opazo, C., Aguayo, LG,,…, van Zundert, B. PSD95 suppresses dendritic arbor development in mature hippocampal neurons by occluding the clustering of NR2B-NMDA receptors. 2014. PLoS One 9(4):e94037.
- Araya, JA., Ramirez, AE., Figueroa-Aroca, D., Sotes, GJ., Perez, C., Becerra, J., Saez-Orellana, F., Guzman, L., Aguayo, LG., Fuentealba, J. J. Modulation of neuronal nicotinic receptor by quinolizidine alkaloids causes neuroprotection on a cellular Alzheimer model. 2014. Alzheimers Disease 42(1):143-155.
Aguayo Hernández Luis Gerardo
Libros
- Peters C, Fernandez-Perez E, Fuentealba J, Aguayo LG. 2015. Neurotoxicity of Aβ explained by its association to plasma membranes. Synaptic Fundamentals of Memory Performance Nova Science Publishers Inc, New York. Edited by Ignacio Gonzalez-Burgos. Chapter 8, pp175-192.
- Fuentealba J, Godoy P, Silva-Grecchi T, Saez-Orellana F, Aguayo LG. 2015. Cellular and molecular targets as starting points to attenuate the synaptic failure in Alzheimer beta amyloid toxicity: the purinergic transmission.“Synaptic Fundamentals of Memory Performance”. Nova Science Publishers Inc, New York. Edited by Ignacio Gonzalez-Burgos. In ebook, chapter 9, pp193-212.